Blar i forfatter "Vanic, Zeljka"

Viser treff 1-9 av 9

    • Azithromycin-liposomes as a novel approach for localized therapy of cervicovaginal bacterial infections 

      Vanic, Zeljka; Rukavina, Zora; Manner, Suvi; Fallarero, Adyary; Uzelac, Lidija; Kralj, Marijeta; Amidzic Klaric, Danijela; Bogdanov, Anita; Raffai, Timea; Virok, Deszo Peter; Filipovic-Grcic, Jelena; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-30)
      <p><i>Background - </i>Efficient localized cervicovaginal antibacterial therapy, enabling the delivery of antibiotic to the site of action at lower doses while escaping systemic drug effects and reducing the risk of developing microbial resistance, is attracting considerable attention. Liposomes have been shown to allow sustained drug release into vaginal mucosa and improve delivery of antibiotics ...

    • Elastic liposomes-in-vehicle formulations destined for skin therapy: the synergy between type of liposomes and vehicle 

      Palac, Zora; Hurler, Julia; Skalko-Basnet, Natasa; Filipovic-Grcic, Jelena; Vanic, Zeljka (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-07-14)

    • Liposomes for (trans)dermal drug delivery: the skin-PVPA as a novel in vitro stratum corneum model in formulation development 

      Palac, Zora; Engesland, André; Flaten, Gøril Eide; Skalko-Basnet, Natasa; Filipovic-Grcic, Jelena; Vanic, Zeljka (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-03-19)
      Penetration potential of vesicles destined for trans(dermal) administration remains to be of great interests both in respect to drug therapy and cosmetic treatment. This study investigated the applicability of the phospholipid vesicle-based permeation assay (PVPA) as a novel in vitro skin barrier model for screening purposes in preformulation studies. Various classes of liposomes containing hydrophilic ...

    • Mucoadhesive liposomal delivery systems : the choice of coating material 

      Karn, Pankaj Ranjan; Vanic, Zeljka; Pepic, Ivan; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Development of liposomal mucoadhesive drug delivery system, which is able to improve the bioavailability of poorly absorbed oral drugs by prolonging their gastric and intestinal residence time, through facilitating the intimate contact of the delivery system with the absorption membrane. Liposomes containing model drug atenolol were prepared by the modified ethanol injection method. Liposomes ...

    • Nanomedicines for the topical treatment of vulvovaginal infections: Addressing the challenges of antimicrobial resistance 

      Vanic, Zeljka; Jøraholmen, May Wenche; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-30)
      Recent years have, surprisingly, witnessed an increase in incidence of sexually transmitted infections (STIs). At the same time, antimicrobial therapy came under the threat of ever rising antimicrobial resistance (AMR), resulting in STIs with extremely limited therapy options. In this review, we addressed the challenges of treating vaginal infections in an era of AMR. We focused on published work ...

    • Nanopharmaceuticals for improved topical vaginal delivery: Can they deliver? 

      Vanic, Zeljka; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Nanopharmaceuticals have the potential to revolutionise medical treatment by permitting the design of more potent, less toxic “smart” therapeutics, ultimately leading to personalised medicine. This review summarises the challenges and potential uses of nanodelivery system for the topical drug therapy of vaginal diseases. The vaginal route of drug administration remains a challenge in the development ...

    • A Novel Approach for the Treatment of Aerobic Vaginitis: Azithromycin Liposomes-in-Chitosan Hydrogel 

      Cacic, Ana; Amidžic Klaric, Daniela; Keser, Sabina; Radikovic, Maja; Rukavina, Zora; Jøraholmen, May Wenche; Uzelac, Lidija; Kralj, Marijeta; Skalko-Basnet, Natasa; Segvic Klaric, Maja; Vanic, Zeljka (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-28)
      Biocompatible mucoadhesive formulations that enable a sustained drug delivery at the site of action, while exhibiting inherent antimicrobial activity, are of great importance for improved local therapy of vaginal infections. The aim of this research was to prepare and evaluate the potential of the several types of azithromycin (AZM)-liposomes (180–250 nm) incorporated into chitosan hydrogel (A ...

    • Pectosomes and Chitosomes as Delivery Systems for Metronidazole: The One-Pot Preparation Method 

      Andersen, Toril; Vanic, Zeljka; Flaten, Gøril Eide; Mattsson, S.; Tho, Ingunn; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Mucoadhesive liposomes offer a potential for improved residence time of liposomal systems targeting contact with mucosal tissues, such as in buccal, oral, colon, and vaginal drug delivery. Most of the currently available methods rely on the coating of preformed liposomes by various mucoadhesive polymers. The aim of this study was to develop novel mucoadhesive system by the one-pot preparation method. ...

    • Tailored anti-biofilm activity – Liposomal delivery for mimic of small antimicrobial peptide 

      Hemmingsen, Lisa Myrseth; Giordani, Barbara; Paulsen, Marianne Hagensen; Vanic, Zeljka; Flaten, Gøril Eide; Vitali, Beatrice; Basnet, Purusotam; Bayer, Annette; Strøm, Morten B.; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-13)
      The eradication of bacteria embedded in biofilms is among the most challenging obstacles in the management of chronic wounds. These biofilms are found in most chronic wounds; moreover, the biofilm-embedded bacteria are considerably less susceptible to conventional antimicrobial treatment than the planktonic bacteria. Antimicrobial peptides and their mimics are considered attractive candidates in the ...